abstract：:Exposure to ionizing radiation alone or combined with traumatic tissue injury is a crucial life-threatening factor in nuclear and radiological incidents. Radiation injuries occur at the molecular, cellular, tissue and systemic levels; their mechanisms, however, remain largely unclear. Exposure to radiation combined wi...

journal_title：Radiation research

authors： Kiang JG,Zhai M,Bolduc DL,Smith JT,Anderson MN,Ho C,Lin B,Jiang S

更新日期：2017-11-01 00:00:00

abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...

journal_title：Radiation research

authors： Thome C,Mitz C,Hulley EN,Somers CM,Manzon RG,Wilson JY,Boreham DR

更新日期：2017-10-01 00:00:00

abstract：:The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to ma...

journal_title：Radiation research

authors： Hill MA,Thompson JM,Kavanagh A,Tullis IDC,Newman RG,Prentice J,Beech J,Gilchrist S,Smart S,Fokas E,Vojnovic B

更新日期：2017-09-01 00:00:00

abstract：:Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer treatment. LEEs have been shown to efficiently produce complex molecular damage resulting in substantial cellular toxicities. Sinc...

journal_title：Radiation research

authors： Rezaee M,Hill RP,Jaffray DA

更新日期：2017-08-01 00:00:00

abstract：:Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We studied the properties of two human cell lines, M059K glioma and U2OS ost...

journal_title：Radiation research

authors： Nakajima H,Furukawa C,Chang YC,Ogata H,Magae J

更新日期：2017-08-01 00:00:00

abstract：:Deep-space travel presents risks of exposure to ionizing radiation composed of a spectrum of low-fluence protons (1H) and high-charge and energy (HZE) iron nuclei (e.g., 56Fe). When exposed to galactic cosmic rays, each cell in the body may be traversed by 1H every 3-4 days and HZE nuclei every 3-4 months. The effects...

journal_title：Radiation research

authors： Sasi SP,Yan X,Zuriaga-Herrero M,Gee H,Lee J,Mehrzad R,Song J,Onufrak J,Morgan J,Enderling H,Walsh K,Kishore R,Goukassian DA

更新日期：2017-08-01 00:00:00

abstract：:In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there e...

journal_title：Radiation research

authors： DiCarlo AL,Tamarat R,Rios CI,Benderitter M,Czarniecki CW,Allio TC,Macchiarini F,Maidment BW,Jourdain JR

更新日期：2017-08-01 00:00:00

abstract：:Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to th...

journal_title：Radiation research

authors： Fan XW,Liu HH,Wang HB,Chen F,Yang Y,Chen Y,Guan SK,Wu KL

更新日期：2017-06-01 00:00:00

abstract：:Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in gluc...

journal_title：Radiation research

authors： Zahra A,Fath MA,Opat E,Mapuskar KA,Bhatia SK,Ma DC,Rodman SN III,Snyders TP,Chenard CA,Eichenberger-Gilmore JM,Bodeker KL,Ahmann L,Smith BJ,Vollstedt SA,Brown HA,Hejleh TA,Clamon GH,Berg DJ,Szweda LI,Spitz DR,Buat

更新日期：2017-06-01 00:00:00

abstract：:In the event of a large-scale radiation exposure, accurate and quick assessment of radiation dose received would be critical for triage and medical treatment of large numbers of potentially exposed individuals. Current methods of biodosimetry, such as the dicentric chromosome assay, are time consuming and require soph...

journal_title：Radiation research

authors： Park JG,Paul S,Briones N,Zeng J,Gillis K,Wallstrom G,LaBaer J,Amundson SA

更新日期：2017-06-01 00:00:00

abstract：:Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious effects on quality of life for affected patients. We hypothesize that cerebrova...

journal_title：Radiation research

authors： Andrews RN,Metheny-Barlow LJ,Peiffer AM,Hanbury DB,Tooze JA,Bourland JD,Hampson RE,Deadwyler SA,Cline JM

更新日期：2017-05-01 00:00:00

abstract：:The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initiall...

journal_title：Radiation research

authors： Marino SA

更新日期：2017-04-01 00:00:00

abstract：:Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation...

journal_title：Radiation research

authors： Yan C,Luo L,Urata Y,Goto S,Guo CY,Li TS

更新日期：2017-02-22 00:00:00

abstract：:The concept of curvature in dose-response relationships figures prominently in radiation biology, encompassing a wide range of interests including radiation protection, radiotherapy and fundamental models of radiation action. In this context, the ability to detect even small amounts of curvature becomes important. Sta...

journal_title：Radiation research

authors： Shuryak I,Loucas BD,Cornforth MN

更新日期：2017-01-01 00:00:00

abstract：:There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...

journal_title：Radiation research

authors： Rabender C,Mezzaroma E,Mauro AG,Mullangi R,Abbate A,Anscher M,Hart B,Mikkelsen R

更新日期：2016-11-01 00:00:00

abstract：:Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a ...

journal_title：Radiation research

authors： Choofong S,Cloutier P,Sanche L,Wagner JR

更新日期：2016-11-01 00:00:00

abstract：:Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization). While it is known that mismatches in DNA are necessary for dFdCyd radiosensitization, the critical event resulting in radiosensitization has not been identifie...

journal_title：Radiation research

authors： Im MM,Flanagan SA,Ackroyd JJ,Knapp B,Kramer A,Shewach DS

更新日期：2016-11-01 00:00:00

abstract：:Current therapeutic approaches for treatment of exposure to radiation involve the use of antioxidants, chelating agents, recombinant growth factors and transplantation of stem cells (e.g., hematopoietic stem cell transplantation). However, exposure to high-dose radiation is associated with severe damage to the vascula...

journal_title：Radiation research

authors： Rafii S,Ginsberg M,Scandura J,Butler JM,Ding BS

更新日期：2016-08-01 00:00:00

abstract：:Hemodynamic shear stress is defined as the physical force exerted by the continuous flow of blood in the vascular system. Endothelial cells, which line the inner layer of blood vessels, sense this physiological force through mechanotransduction signaling and adapt to maintain structural and functional homeostasis. Hem...

journal_title：Radiation research

authors： Natarajan M,Aravindan N,Sprague EA,Mohan S

更新日期：2016-08-01 00:00:00

abstract：:Animal models of hematopoietic and gastrointestinal acute radiation syndromes (ARS) have been characterized to develop medical countermeasures. Acute radiation-induced decrease of intestinal absorptive function has been correlated to a decrease in the number of intestinal crypt cells resulting from apoptosis and enter...

journal_title：Radiation research

authors： Bujold K,Hauer-Jensen M,Donini O,Rumage A,Hartman D,Hendrickson HP,Stamatopoulos J,Naraghi H,Pouliot M,Ascah A,Sebastian M,Pugsley MK,Wong K,Authier S

更新日期：2016-07-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:Diethylenetriaminepentaacetic acid (DTPA) is currently still the only known chelating drug that can be used for decorporation of internalized plutonium (Pu) and americium (Am). It is generally assumed that chelation occurs only in biological fluids, thus preventing Pu/Am deposition in target tissues. We postulate that...

journal_title：Radiation research

authors： Grémy O,Laurent D,Coudert S,Griffiths NM,Miccoli L

更新日期：2016-06-01 00:00:00

abstract：:Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data fr...

journal_title：Radiation research

authors： Veiga LH,Holmberg E,Anderson H,Pottern L,Sadetzki S,Adams MJ,Sakata R,Schneider AB,Inskip P,Bhatti P,Johansson R,Neta G,Shore R,de Vathaire F,Damber L,Kleinerman R,Hawkins MM,Tucker M,Lundell M,Lubin JH

更新日期：2016-05-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) is an aggressive disease with a high risk of recurrence and death. Here, we present a novel strategy to enhance the radiotherapy of TNBC by combining gold nanoparticles (AuNPs) with pentamidine, a clinically approved anti-parasitic agent with anti-cancer properties. The radiosensit...

journal_title：Radiation research

authors： Her S,Cui L,Bristow RG,Allen C

更新日期：2016-05-01 00:00:00

abstract：:Reproductive cell death (RCD) occurs after one or more cell divisions resulting from an insult such as radiation exposure or other treatments with carcinogens or mutagens. The radioadaptive response for RCD is usually investigated by in vitro or in vivo clonogenic assay. To date, this has not been demonstrated in the ...

journal_title：Radiation research

authors： Tang H,Chen L,Liu J,Shi J,Li Q,Wang T,Wu L,Zhan F,Bian P

更新日期：2016-04-01 00:00:00

abstract：:Mathematical analysis of cell survival allows parameter estimation for radiobiological models and selection of an appropriate model. To our knowledge, no rigorous comparisons on the accuracy of various methods used for such analysis have been performed. In this study we compared three methods: 1. maximization of binom...

journal_title：Radiation research

authors： Shuryak I,Sun Y,Balajee AS

更新日期：2016-03-01 00:00:00

abstract：:Synchrotron microbeam radiation treatment (MRT) is a preclinical radiotherapy technique with considerable clinical promise, although some of the underlying radiobiology of MRT is still not well understood. In recently reported studies, it has been suggested that MRT elicits a different tumor immune profile compared to...

journal_title：Radiation research

authors： Ibahim MJ,Yang Y,Crosbie JC,Stevenson A,Cann L,Paiva P,Rogers PA

更新日期：2016-01-01 00:00:00

abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...

journal_title：Radiation research

authors： Wang J,Shao L,Hendrickson HP,Liu L,Chang J,Luo Y,Seng J,Pouliot M,Authier S,Zhou D,Allaben W,Hauer-Jensen M

更新日期：2015-11-01 00:00:00

abstract：:We report here on a qualitative and quantitative comparison of four kinetic photon cell survival models. The commonly used linear-quadratic model extended by a dose protraction factor, the lethal potentially lethal model, the repair misrepair model and the recently reported Giant LOop Binary LEsion (GLOBLE) model are ...

journal_title：Radiation research

authors： Herr L,Friedrich T,Durante M,Scholz M

更新日期：2015-11-01 00:00:00

abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...

journal_title：Radiation research

authors： Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun S

更新日期：2015-09-01 00:00:00

abstract：:Astronauts traveling outside Earth's magnetosphere risk exposure to charged particle radiation that may cause neurophysiological changes and behavioral deficits. Although proton particles comprise a large portion of the space radiation environment, little has been published on the effects of low-dose proton radiation ...

journal_title：Radiation research

authors： Bellone JA,Rudobeck E,Hartman RE,Szücs A,Vlkolinský R

更新日期：2015-08-01 00:00:00

abstract：:There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...

journal_title：Radiation research

authors： Sproull M,Kramp T,Tandle A,Shankavaram U,Camphausen K

更新日期：2015-07-01 00:00:00

abstract：:Intestinal microbiota affect cell responses to ionizing radiation at the molecular level and can be linked to the development of the immune system, controlled cell death or apoptosis. We have developed a microbiota mouse model and report here that high-linear energy transfer (LET) radiation induced the repair of chrom...

journal_title：Radiation research

authors： Maier I,Schiestl RH

更新日期：2015-06-01 00:00:00

abstract：:Molecular oxygen has long been recognized as a powerful radiosensitizer that enhances the cell-killing efficiency of ionizing radiation. Radiosensitization by oxygen occurs at very low concentrations with the half-maximum radiosensitization at approximately 3 mmHg. However, robust hypoxia-induced signal transduction c...

journal_title：Radiation research

authors： Liu C,Lin Q,Yun Z

更新日期：2015-05-01 00:00:00

abstract：:Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot be repaired. However, in this study we found that a delayed increase of mitochondrial reactive oxygen species (ROS) is responsible for some of the radiation-induced cell death in normal human fibroblast cells. We have previously rep...

journal_title：Radiation research

authors： Kobashigawa S,Kashino G,Suzuki K,Yamashita S,Mori H

更新日期：2015-04-01 00:00:00

abstract：:Radiation-induced complications in bone and cartilage are of increasing concern due to potential long-term effects in cancer survivors. Healthy articular cartilage may be exposed to radiation during either chondrosarcoma treatment or in-field radiotherapy of tumors located in close proximity to articulation. Cartilage...

journal_title：Radiation research

authors： Saintigny Y,Cruet-Hennequart S,Hamdi DH,Chevalier F,Lefaix JL

更新日期：2015-02-01 00:00:00

abstract：:Both plant senescence and plant response to ionizing radiation involve changes in gene expression and epigenetic profiles, that rely on the formation of reactive oxygen species. However, how the developmental stage of a plant affects its response to ionizing radiation has not been extensively studied. In this study, o...

journal_title：Radiation research

authors： Sidler C,Li D,Kovalchuk O,Kovalchuk I

更新日期：2015-02-01 00:00:00

abstract：:Clustered DNA damage is considered an important factor in determining the biological consequences of ionizing radiation. In this study, we successfully estimated the localization of abasic sites (APs) in DNA exposed to ionizing radiation using fluorescence resonance energy transfer (FRET) without any involvement of re...

journal_title：Radiation research

authors： Akamatsu K,Shikazono N,Saito T

更新日期：2015-01-01 00:00:00

abstract：:In this article, we describe recent methodological enhancements and findings from the dose reconstruction component of a study of health risks among U.S. radiologic technologists. An earlier version of the dosimetry published in 2006 used physical and statistical models, literature-reported exposure measurements for t...

journal_title：Radiation research

authors： Simon SL,Preston DL,Linet MS,Miller JS,Sigurdson AJ,Alexander BH,Kwon D,Yoder RC,Bhatti P,Little MP,Rajaraman P,Melo D,Drozdovitch V,Weinstock RM,Doody MM

更新日期：2014-11-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00